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The pathophysiology of hepatic encephalopathy is associated with impaired interaction between astrocytes, neurons, cerebral blood flow, and cerebral oxygen consumption 4,5,43,47,48,49

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SMN deficiency causes tissue-specific perturbations in the repertoire of snRNAs and widespread defects in splicing

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Studies were evaluated based on criteria including study design, sample size, blinding, outcome measures, and statistical analysis