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Lastly, blocking GPX4 abolishes the antidepressant effects of EDA, confirming the regulatory role of the Sirt1/Nrf2/HO-1/GPX4 signaling pathway in ferroptosis, with GPX4 serving as a crucial component in the treatment of depression and anxiety via ferroptosis mechanisms (Dang et al., 2022)

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doi: 10.1002/anie.201406357 217 LengS.ZhangW.ZhengY.LibermanZ.RhodesC

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Understanding how targeted fat loss affects lipid metabolism could inform the development of interventions for dyslipidemia and atherosclerosis prevention

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