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dosing should be appropriate to the indication and duration overseen by a clinician

The evidence summarised in this review is limited and indirectly addresses the reviews research question as many of the studies used artificially induced resistant or susceptible organisms, which may not reflect the mechanisms that develop in field settings

BMB Rep 2018;51:429-36

Notably, Syrian hamsters given low doses of an RBD-specific neutralizing mAb prior to challenge with SARS-CoV-2 showed a trend for greater weight loss than control animals 82 , though differences were not statistically significant and the low-dose animals had lower viral loads in the lung compared to control animals