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Structural optimization research focuses on understanding molecular determinants of peptide efficacy and selectivity through detailed protein-protein interaction studies

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In an attempt to provide some understanding of the possible physiological role of this enzyme in red cells, we were led to an examination of the metabolism of glutathione

Using in vitro human models, we showed that these thiomethyl metabolites are directly linked to NAPQI detoxification since they are mainly formed after exposure to glutathione-derived conjugates via an overlooked pathway called the thiomethyl shunt

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