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Annu Rev Physiol 78:277299
To receive an Addisons disease diagnosis, you must have lost 90% of your adrenal glands function
Subsequently, many other data were accumulated for a variety of biological systems [260,261,262], including human tissue models [263] and human tissue irradiated in vivo, where, however, a considerable individual variability in radiation response was observed [264]
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Essentially, the identical phenotype was seen in cyclin D-knockout mice, thereby confirming the role of D-cyclins as CDK4/6 activators in vivo (8)
