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These findings were further confirmed in a Thy1-ASO mouse model, where curli-producing bacteria ( E

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G-protein-mediated signaling can also contribute to both therapeutic and adverse outcomes, and differences in intrinsic efficacy and receptor reserve can give rise to apparent pathway bias without true pathway-selective engagement

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Inside that outer ring sits the nucleus pulposus , a gelatinous core rich in type II collagen, elastin fibers, and a hydrated proteoglycan gel that gives the disc its shock-absorbing properties

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& Wasserman, D

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