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While there is no evidence of common structural or functional brain alterations in PAIS, probably due to its heterogeneous origin and lack of conceptualization, ME/CFS has been extensively studied with MRI (magnetic resonance imaging), as recently reviewed by Nelson et al

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In addition, since FMO3 plays a systemic role in catecholamine metabolism, inhibiting its function may not be innocuous ( Conclusions AS is a complex disease, which makes characterizing its underlying mechanisms difficult