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The defining characteristic is the durable growth arrest, typically enforced by the activation of tumor suppressor pathways involving key cell cycle inhibitors like p16 Ink4a (encoded by CDKN2A ) and p21 Cip1 (encoded by CDKN1A ), often acting via p53 and the retinoblastoma protein (pRB) [50, 51]
2023, 79, 102530 10.1016/j.sbi.2023.102530
The treatment was also associated with a significant increase in taurine content in fast-twitch limb muscles, suggesting that dystrophic muscle maintains the ability to uptake taurine if adequately supplemented [58]
Recent reports have suggested that mitochondrial dysfunction is closely related to a variety of neurodegenerative diseases including PD (Exner et al., 2012
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