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Under hypoxia or metabolic stress, HIF-1 activation induces multi-drug resistance by upregulating efflux transporters such as P-glycoprotein (P-gp/MDR1), enforcing G1 cell-cycle arrest, and stimulating antioxidant and DNA repair programs that confer radioresistance [326, 327]
Antimicrobial therapy is indicated to eradicate the organism from the nasopharynx and decrease transmission
Pharmaceuticals 16
doi: 10.1097/00004583-199003000-00004
Understanding these mechanisms is crucial for developing effective strategies to prevent and treat skin aging, ultimately improving skin health and appearance [7]
