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Integrated analysis of our lipidomic and transcriptomic data highlights a coordinated alteration of the sphingolipid metabolism pathway

20/40/40/1.5 mol/mol) liposomal LNP system in comparison to LNP mRNA systems with the Onpattro-like lipid composition

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combined the Nimzyme method with an accurate mass tagging approach, utilizing unique perfluorinated tails on each reactant to analyze the stereospecific reaction pathways for three stereoisomers (maltose, lactose, and cellobiose) that produce the same product glucose, on a traditional MALDI-TOF instrument

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