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It is unknown whether MOUNJARO causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans as human relevance of tirzepatide-induced rodent thyroid C-cell tumors has not been determined [see Warnings and Precautions (5.1) and Nonclinical Toxicology (13.1)]

Drug interactions represent another area of uncertainty

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Neuroadaptive processes in GABAergic and glutamatergic systems in benzodiazepine dependence

When gabapentin or pregabalin are being discontinued, the dose should be tapered over at least a one-week period
