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Similarly, in the current study, DIO mice from both groups that were switched from WD to LD exhibited higher Bacteroidetes and significantly lower Firmicutes relative abundances compared to DIO mice maintained on WD (WD controls

These include itching, acne, nausea, diarrhea, vascular thrombosis, headache, nervousness, and dizziness

Comprehensive laboratory monitoring showed no clinically significant changes in hematology, biochemistry, or urinalysis parameters

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