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Glutaminase inhibitors, such as CB-839, have shown promise in preclinical studies and early-phase clinical trials, demonstrating their ability to impede glutamine catabolism and disrupt the supply of glutamate, a precursor for numerous biosynthetic pathways critical for cancer cell survival and proliferation [12,55]

It is characterized by a diminished ability to respond to pathogens, reduced vaccine efficacy, and an increased risk of age-related diseases