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This reaction is catalyzed by the enzyme glutamate cysteine ligase (GCL), which is also called -glutamylcysteine synthetase (Fig

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In diazepam chronically treated mice, it attenuated diazepam tolerance (provoked by later acute administration of diazepam together with convulsant) and postponed physical dependence/withdrawal effects (provoked by later administration of isoniazid)