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In addition, Nrf2 has been shown to be involved in the unfolded protein response (UPR), which is triggered by the accumulation of misfolded proteins in the ER lumen (104, 176)

Disulfidptosis Disulfidptosis is a form of PCD induced by glucose starvation in SLC7A11-overexpressing cells, where reduced NADPH production impairs cysteine-to-cystine conversion, causing cysteine accumulation and disulfide stress

[DOI] [PMC free article] [PubMed] [Google Scholar] 43.Hinson J.A., Pike S.L., Pumford N.R
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