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glutathione peroxidase reductase enzyme system 4: a new player in neurodegeneration? Glutathione system with synthesis routes
Description
Genome and biochemical analyses of pathogenic and commensal species revealed that all Neisseria species have a highly conserved nitric oxide reductase (NorB) and nitrite reductase (AniA or NirK), while only Neisseria mucosa contained a nitrate reductase (Nar), and only Neisseria lactamica , Neisseria cinerea , Neisseria subflava , Neisseria flavescens , and Neisseria sicca contained a nitrous oxide reductase (Nos) complex (Barth et al., 2009)
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The same pathway that promotes synaptogenesis also plays roles in cell proliferation more broadly
This dysregulation is characterized by persistent activation of PERK-eIF2 [329], upregulation of ATF4/CHOP [330], and the inflammatory signaling mediated by IRE1 [331]