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IGF-1, diabetes, and hyperinsulinemia A link between decreased circulating IGF-1 and MetS components, such as dyslipidemia and DM, has been observed (15, 161) but remains questionable due to conflicting findings in the literature

Moreover, according to a small randomised, double-blind, cross-over study (ClinicalTrials.gov identifier: NCT00693355) involving 16 healthy volunteers, rectal administration of butyrate significantly increased glutathione concentration in colonic biopsies compared to placebo

- Antioxidant

& Esmaillzadeh, A

Selenium, cadmium (Cd), arsenic (As), and lead (Pb) in particular have attracted a lot of study due to their complex relationships with thyroid function and trace elements [3]
