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Over-loss and muscle pooled SURMOUNT, BMI below 22 reached by about 7% (as early as week 12), toward about 15% by week 88 in the longest trial, clinical underweight under 0.4% (Almandoz 2026)

Instead, they can be a supplementary aid in a comprehensive weight loss plan that includes proper nutrition and physical activity

Different mechanisms, overlapping tissue endpoints hence the frequent combination in research protocols

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[DOI] [PubMed] [Google Scholar] 77.Becejac T., Cesarec V., Drmic D., Hirsl D., Madzarac G., Djakovic Z., Bunjevac I., Zenko Sever A.A., Sepac A., Vuletic L.B., et al