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Another area of growing interest is the role of astrocyte-neuron interactions in maintaining GSH homeostasis: astrocytes synthesize GSH by importing cystine via the cystine/glutamate antiporter (Sxc ) and glutamine synthetase, releasing GSH directly through pannexin-1 channels or gap junctions (Cx43), while regulating extracellular glutamate levels via excitatory amino acid transporter 1/2(EAAT1/2) transporters to sustain neuronal GSH precursor supply, thereby mediating neuroprotection under oxidative stress (Verkhratsky and Nedergaard, 2018)

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