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The increased potencies of the IGF-I variants may relate to the substantially increased plasma levels of IGF-binding proteins, particularly IGFBP-3, produced by the combined treatment of dexamethasone with IGF-I or the variants

Potential reduction in depression, cognitive decline, and dementia risk, particularly in older individuals

Investigating whether ferroptosis contributes differentially to these subphenotypes could provide valuable insights for personalized therapies
