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Best practice is to use modifier 25 only when the documentation clearly supports a separate E/M service
Scientific references The following are independent, peer-reviewed publications provided for reference
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The metabolism and clearance of both components may be affected by significant liver disease, and patients with severe hepatic impairment should be monitored closely if treatment is deemed necessary
The abdomen and anterior thigh remain preferred due to ease of access, larger surface area for rotation, and consistent adipose thickness across most body compositions
