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Western blotting of separating nuclear and cytoplasmic extracts revealed a significant increase in FOXO4 expression in H 2 O 2 -induced senescent TM3 Leydig cells, and confirmed that FOXO4 protein was concentrated in the nucleus (Figure 3C3E)
Graphical abstract Similar content being viewed by others Introduction Diseases of the central nervous system (CNS), including Alzheimer's disease, Parkinson's disease, stroke, and brain tumors, have affected the normal lives of an increasing number of people worldwide in recent years[1,2,3]
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