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Considering that PDCs increased the local concentration of cytotoxic agents in tumor tissues, they can reduce cytotoxic effects to normal tissues and increase therapeutic efficacy
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Here are the signs of a B12 deficiency
Inhibition of vitamin K epoxidase decreases the synthesis of these clotting factors, but the complex has a long half-life (about 14 hours), and it is this half-life that determines how long it takes for the concentration of clotting factors to reach a new steady state and for a drug effect to reflect the average warfarin plasma concentration
