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Together with the kinetic model and its full numerics of the expression derived for the doseresponse relation, an approximated form of the expression clarifies the role played by the individual biochemical processes and allows us to identify four distinct regimes for the downregulation that emerge from the balance between phosphorylation, dephosphorylation, and the cellular level of -arrestin.

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Subnormal alkaline phosphatase levels may indicate the presence of hypophosphatasia, Wilsons disease, deficiencies of divalent ions, or malnutrition