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Both studies also reported relative safety and no side effects that may otherwise occur with exogenous hGH use [2]: No statistically significant differences in IGF-1 levels were observed among the treatment and placebo groups throughout the study

In diet-induced obesity (DIO) models, NNMT loss-of-function and selective small-molecule inhibitors reduce white adipose mass and improve metabolic parameters without overt toxicity, positioning NNMT as a tractable target for metabolic-disease research [24]

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Someone with low blood pressure might notice no change or even a slight increase as compensatory mechanisms activate
