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Next, we asked if increased ferroptosis sensitivity in N1IC cells is specifically linked to GPX4 dependency

Heatmap generation Heatmap indicating transcript abundance and expression pattern was generated using the HEATMAP hierarchical clustering web tool ( The log2 fold-change values of relative expression levels (the 2 (Ct) value) were used to construct the heatmap

Increasing glutathione and its supporting enzymes has been shown to reduce oxidative damage and help remove toxic substances from the body

In contrast, Igf1 mRNA levels showed significantly increased levels in both CreERT2 experimental groups indicating IGF1 resistance to the IGF1R-defiency condition