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The authors proposed that L-carnitine regulates the PTEN/Akt/mTOR signaling pathway, and enhances axonal plasticity while concurrently ameliorating oxidative stress and increasing oligodendrocyte myelination of axons and suggested that this attenuated cognitive impairment after chronic hypoperfusion [86] However, the increased CPT I and CPT II protein levels in L-carnitine treated rats may also have protected myelin after chronic hypoperfusion

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VPA is used to treat psychiatric disorders and as such there is an association with accidental or deliberate overdose, the incidence of which is increasing [135, 136]

It is characterized by the fact that its double bonds are separated by only one single bond, which is rare in nature

doi: 10.1007/s12264-013-1423-y