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Description
In Stage 2, Communalytic reviews all the submissions collected during Stage 1 and retrieves corresponding comments and replies via PRAWs Submission.comments call

Investigational Uses of NAC in Rare Diseases In addition to the approved indications of NAC discussed above, there are case reports and clinical studies reported in the literature that explored the potential uses of NAC in a variety of disease conditions

[184] found that SAMe prevented 5-HT 1A receptor up-regulation induced by acute imipramine in the frontal cortex, which may contribute to the augmentation effect of SAMe [184]

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Thus, a metabolomics perspective was used in this study
