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These disruptions have been found to impair communication in the MGBA, a pathway increasingly linked to psychiatric symptoms ( Figure 10 Although emerging evidence links xenobiotics, such as antibiotics (most commonly prescribed pharmaceuticals), glyphosate (most widely used herbicide), and microplastics (MPs)(ubiquitous emerging environmental contaminant) with anxiety and depression, studies remain limited and mechanisms of action are poorly understood (Zhang et al., 2021a

Multi-center pre-clinical consortia to enhance translation of therapies and biomarkers for traumatic brain injury: Operation brain trauma therapy and beyond

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A mechanistic study indicated that the combined administration of TSA and As-IV exerted anti-apoptotic, antioxidant and anti-inflammatory effects in MIRI by synergistically inhibiting the STING pathway, with superior efficacy compared with monotherapy (127)

Moreover, not all methodologies utilized in these studies are properly validated against the gold standard, i.e., the Ussing chamber, and therefore caution is needed in the interpretation of these permeability data