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HIF is a transcription factor that responds to cellular oxygen supply

CoronaVac: a review of efficacy, safety, and immunogenicity of the inactivated vaccine against SARS-CoV-2

doi: 10.1111/j.1396-0296.2004.04019.x
In this case, the needle is withdrawn and redirected slightly caudally and laterally

10.1152/japplphysiol.00864.2011 J Appl Physiol (1985)