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They either donate or accept an electron, therefore acting as oxidants and reductants (Lobo et al., 2010)

On the other side, it also limits water loss by improving the skin barrier with increased lipid (ceramides and cholesterol) and protein synthesis

It confirmed ferroptosis as the core mechanism in PD pathogenesis synergistically induced by iron overload and inflammation, which activate ferroptosis by disrupting iron metabolism, inhibiting the antioxidant system and exacerbating lipid peroxidation, further causing dopaminergic neuronal damage, -syn aggregation, and PD-characteristic motor/cognitive impairments (186).Treating SH-SY5Y dopamine neurons with rotenone and using RhoNox-1 staining, followed by confocal microscopy observation and flow cytometry analysis, revealed significantly higher intracellular Fe 2+ in the rotenone group, confirming cellular iron overload (187)

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New approach to treat allergic rhinitis with vitamin E, cod liver oil and vitamin C with use of nasal steroidal spray