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The exact reasons are unclear, but vitamin Ds effects on pain and inflammation might play a role
Folinic acid (Leucovorin) is the preferred form of folate for addressing low brain folate in autism because it bypasses folate receptor blockade and provides a usable form of folate without requiring conversion by DHFR

Common in obesity and metabolic syndrome

Rare risks include copper toxicity, particularly in individuals with underlying conditions such as Wilsons disease (a genetic disorder causing copper accumulation), and theoretical concerns regarding angiogenesis promotion in the context of active cancers

C., Lin, M
