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HIF-1 is a key transcription factor that regulates glucose metabolism and stimulates glycolytic gene expression during hypoxic conditions (73)

Neuroactive peptides work through mechanisms such as brain-derived neurotrophic factor (BDNF) upregulation, HGF/c-Met signaling, and modulation of monoamine neurotransmitters (Table 4)

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After 5 weeks dosing, C57BL/6NTac and C57BL/6J cpz treated animals exhibited significant differences in FA in measured subregions of the CC, in comparison to their corresponding vehicle controls (Figure 2A-C)