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Male PRLomas, compared to females, tend to be larger and more invasive, are associated with higher PRL concentration at diagnosis, present higher proliferative potential, are more frequently resistant to standard pharmacotherapy, and thus may require multimodal approach, including surgical resection, radiotherapy, and alternative medical agents

The additional content of clinical features of specimens are showed in Supplementary Table 1

An assumption of parametric analyses that was not tested by the tool was a lack of outliers

doi: 10.1016/0006-2952(90)90503-d

Both routes are effective, though subcutaneous injection has become more popular due to ease and comfort