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Rasli R, Lee HL, Wasi Ahmad N, Fikri SFF, Ali R, Muhamed KA, et al

Treatment of cystic fibrosis airway cells with cftr modulators reverses aberrant mucus properties via hydration

Acidic hydrolysis reaction occurs by nucleophilic addition of water to the protonated amide, followed by transfer of a proton from oxygen to nitrogen to make the nitrogen a better leaving group, and subsequent elimination

This systems-based approach reflects lessons drawn from peptide pairing research: effective performance support often requires coordinated input across multiple physiological systems