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OPN is known to possess multiple biological and immunoregulatory functions being involved in cell adhesion and providing a chemotactic stimulus for macrophages and astrocytes (Denhardt and Guo, 1993
A 2025 analysis of the European pharmacovigilance database examining over 1.17 billion COVID-19 vaccines found 37 cases per million vaccinations (3.7 per 100,000)
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