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As a selective substrate site-targeting inhibitor of nicotinamide N-methyltransferase (NNMT) the cytosolic enzyme responsible for the methylation of nicotinamide using S-adenosylmethionine (SAM) as a methyl donor 5-Amino-1MQ is studied as a tool compound for investigating NNMT enzyme activity, NAD salvage pathway interactions, and methylation pathway dynamics in controlled in-vitro experimental systems

Kim HI, Kim MK, Lee I, Yun J, Kim EH, Seo SK

This dysfunction can impact reproductive tissues directly

Vitamin B12 (cobalamin) refers to a group of chemically-related cobalt containing molecules involved in cell processes such as DNA synthesis, fatty acid synthesis, energy production and regulation