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doi:10.1080/00016480802566279

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Many senescence-inducing stressors are linked to oncogenic factors, indicating that senescence and apoptosis may have evolved in tandem to inhibit tumor development [210]

TGF- is an important regulator of neovascularization in tumor and it acts in a context-dependent manner by promoting angiogenesis via stimulation of pro-angiogenic factors like VEGF or inhibiting tumor angiogenesis by impairing endothelial cell proliferation and migration or by inducing apoptosis [211]