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The glucocorticoid dexamethasone inhibits HIF-1 stabilization and metabolic reprogramming in lipopolysaccharide-stimulated primary macrophages

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Moderate glutathione synthetase deficiency leads to hemolytic anemia and metabolic acidosis, whereas patients with a more severe deficiency also develop 5-oxoprolinuria, recurrent bacterial infections, and progressive dysfunction of the central nervous system, including mental retardation and motor functional disturbances

Elevated prolactin levels can impair the reproductive function through central (neuroendocrine) and peripheral (gonadal) mechanisms

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