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Indirectly, KD was shown to shed weight along with glycemic control, which protected against oxidative stress in individuals with obesity and type 2 diabetes mellitus (T2DM)

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To generate our tamoxifen-inducible Gdf11 knockout model, mice containing a floxed Gdf11 allele with loxP sites flanking exons 2 and 3 of Gdf11 [1] were bred with Tg(cre/Esr1)5Amc/J mice, obtained from Jackson labs (JAX no