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Speichinger, hormonal imbalances can be caused by a number of different health conditions: thyroid disease like hyperthyroidism or hypothyroidism, polycystic ovary syndrome (PCOS), primary ovarian insufficiency, and hyperprolactinemia, or having too much of a hormone called prolactin in your blood

However, the highly dense arborization of dopaminergic neurons provides overlapping and redundant innervation of the striatum, which leads to increased temporal and spatial effects compared with what can be achieved from a single dopaminergic neuron

Moreover, these molecular changes were accompanied by a phenotypic switch in macrophage polarization, favoring the anti-inflammatory M2 subset over the pro-inflammatory M1 phenotype (Liu et al., 2025)

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GRK4/5/6 either have polybasic domains that bind PIP 2 or have palmitoylated cysteine residues, as in GRK4 and the GRK6a splice variant [34]