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The results indicate that Ru centers exhibit higher electrophilicity, with an electron density of 0.542 |e|, in comparison to Co sites (0.198 |e|) and Ni sites (0.180 |e|), suggesting that Ru centers are more inclined to interact with oxygen species during catalysis (Supplementary Fig

In addition, p53 is known to negatively regulate cellular glycolysis by directly or indirectly inhibiting the expression of glucose transporters (GLUTs) or the translocation of GLUT1 to the plasma membrane, leading to decreased glucose uptake [62,63,64]

Evid Bas Compl Alternat Med

This competition leads to compromised levels of NADPH interfering with the GSH recycling pathway involving conversion of GSSG back to GSH and eventually resulting in diminished levels of GSH [11]