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An animal study conducted by Koeth and colleagues found that TMAO decreases the bile acid pool size and inhibits the expressions of the key BA synthetic enzymes (Cyp7a1 and Cyp27a1) and BA transporters (Oatp1, Oatp4, Mrp2, and Ntcp) in the liver (Koeth et al., 2013)
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10.1038/srep26745 [DOI] [PMC free article] [PubMed] [Google Scholar] Rath S., Heidrich B., Pieper D
