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Systemic Low-Grade Inflammation in Post-Traumatic Stress Disorder: A Systematic Review

Necroptosis can also be materialized as a result of activation of the signaling pathways, due to DNA damage, which leads to the release of apoptosis-related factors from the mitochondrial intermembrane space, followed by the activation of the DNA damagerelated enzyme poly(ADP-ribose) polymerase (PARP) [213]

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doi: 10.3390/antiox11112237

This reward state is mediated by opioids in males and females (Paredes, 2014)
