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In the context of glutathione deficiency or impaired GST activity, this conjugation pathway is compromised, leading to the intracellular accumulation of reactive species and an increased risk of macromolecular damage and cellular dysfunction

10.3389/fnbeh.2017.00015 Front Behav Neurosci

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Jiang, P., Gan, M., Yen, S.-H., McLean, P