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How Oxidative Stress Damages the Brain "Oxidative stress defines a disequilibrium between the levels of reactive oxygen species (ROS) produced and the ability of a biological system to detoxify the reactive intermediates, creating a perilous state contributing to cellular damage." [1] Although the brain makes up only a small fraction of the body's mass, it consumes a whopping 20% of the oxygen we breathe

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This allowed us to observe a higher mitochondrial mass and membrane potential in aged Mda5 -/- HSCs, a characteristic of young HSCs 47,48,49 , albeit in studies utilizing verapamil (Fig