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This review will examine natural products and traditional herbals in GI disorders such as IBS, IBD, GERD, peptic ulcers, and constipation, highlighting mechanisms, efficacy, safety, and the clinical relevance of traditional concepts

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In the blood, once secreted from the pineal gland, melatonin is usually bound to albumin, metabolized to 6-hydroxymelatonin by cytochrome P-450 isoforms and conjugated, in the liver, to produce the principal urinary metabolite, 6-sulfatoxy-melatonin, which is finally eliminated through the kidney 14

Consult your healthcare provider if you are pregnant or planning to become pregnant