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Together with the octasome geometry (this work and reference 29), these data suggest that accommodating CCAN on octasome RG-loop sites would require conformational rearrangement and/or local DNA unwrapping, whereas (CENP-A/H4) 2 tetrasomes provide a CCAN-receptive intermediate via the RG loop

Mahoney LB, Denny CA, Seyfried TN

(2004) The identification of a reaction site of glutathione mixed disulphide formation on S-crystallin in human lens, Biochem

Low-carbohydrate diet and oxidative stress in diabetic and nondiabetic rats

Most of them reported no adverse events at all in both adults and children, while others reported transient adverse events of mild to moderate severity with somnolence, giddiness, drowsiness, epigastric pain/discomfort and vertigo as the most common