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Previous studies have shown that thapsigargin-induced ER stress increases SREBP2 levels in Huh-7 hepatocytes (14)

These findings suggested that busulfan can significantly induce ROS creation and reduce antioxidants, leading to oxidative stress and lipid peroxidation in testicular tissue, which, in turn, can result in germ cell death, spermatogenesis impairment, and infertility (49)

Being older than 35 years of age indeed increases infertility risk (Reference Sharma, Biedenharn and Fedor10)

Its commonly found in coffee, tea, and soft drinks

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