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Most pre-clinical cancer studies only assess for the efficacy of drug(s) in tumor progression, but it is crucial to also identify predictive biomarkers for treatment responses

Upon Hh binding to PTCH, this inhibition is relieved, and SMO can activate a downstream signaling cascade

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Kalinski AL, Kar AN, Craver J, Tosolini AP, Sleigh JN, Lee SJ, Hawthorne A, Brito-Vargas P, Miller-Randolph S, Passino R, Shi L, Wong VSC, Picci C, Smith DS, Willis DE, Havton LA, Schiavo G, Giger RJ, Langley B, Twiss JL (2019) Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition

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